dyclonine hydrochloride
dyclonine hydrochloride
CAS: 536-43-6
Molecular Formula: C18H28ClNO2
dyclonine hydrochloride - Names and Identifiers
| Name | dyclonine hydrochloride |
| Synonyms | Dyclonine HCL DYCLONINE HCL LABOTEST-BB LT00771942 DYCLONINE HYDROCHLORIDE dyclonine hydrochloride Dyclonine, Hydrochloride 4-butoxy-3-piperidinopropiophenone hydrochloride dyclonine hydrochlorideinoline-3-carboxylic acid 1-(4-BUTOXYPHENYL)-3-(1-PIPERIDINYL)-1-PROPANONE HCL 1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanone chloride 1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanonhydrochloride 1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanon hydrochloride 1-(4-BUTOXYPHENYL)-3-(1-PIPERIDINYL)-1-PROPANONE HYDROCHLORIDE |
| CAS | 536-43-6 |
| EINECS | 208-633-6 |
| InChI | InChI=1/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H |
| InChIKey | KNZADIMHVBBPOA-UHFFFAOYSA-N |
dyclonine hydrochloride - Physico-chemical Properties
| Molecular Formula | C18H28ClNO2 |
| Molar Mass | 325.87 |
| Melting Point | 175-176°C |
| Boling Point | 424.5°C at 760 mmHg |
| Flash Point | 210.5°C |
| Water Solubility | Partly soluble in water. Soluble in chloroform, ethanol, acetone and methanol. |
| Solubility | Soluble in DMSO (20 mg/ml); Water (25 mg/ml) |
| Vapor Presure | 2.06E-07mmHg at 25°C |
| Appearance | solid |
| Color | White |
| Merck | 14,3473 |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months. |
| Use | For topical anesthesia |
dyclonine hydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | UG8750000 |
| HS Code | 2933399090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
dyclonine hydrochloride - Introduction
dyclonine hydrochloride, western medicine name. Commonly used dosage forms are mucilage agents. It is a local anesthetic. It is used for laryngeal anesthesia and lubrication during upper gastrointestinal endoscopy, and at the same time remove the foam in the cavity to make the field of vision clear.
Traits
dyclonine hydrochloride mucilage: after shaking well, it is a milky white viscous liquid with a slightly bitter and sour taste, a slight coolness, and a small amount of oil is allowed.
Indications
This product is used for laryngeal anesthesia and lubrication during upper gastrointestinal endoscopy, and at the same time remove the foam in the cavity to make the field of vision clear.
Last Update：2023-08-16 23:19:37
dyclonine hydrochloride - Production method
Piperidine hydrochloride is prepared by the reaction of piperidine and concentrated hydrochloric acid, and p-butoxyacetophenone and paraformaldehyde are added to it, and then concentrated hydrochloric acid is added as a catalyst to obtain crude dyclonine hydrochloride. The crude dyclonine hydrochloride is dissolved in absolute ethanol, activated carbon is added, heated and refluxed, filtered while hot, the filtrate is stirred and cooled, filtered, and vacuum dried to obtain dyclonine hydrochloride.
Last Update：2024-04-09 20:52:54
dyclonine hydrochloride - Reference Information
| Local anesthetic | Duclonine hydrochloride (Dyclonine hydrochloride) is also known as dacolon, and its chemical name is 4-butoxy-β-piperidinyl phenylpropanone hydrochloride. It is a local anesthetic with fast onset, long action time, small adverse reactions and high safety. At present, dyclonine hydrochloride dosage forms that have been listed or reported in China mainly include ointment, cream, liniment, solution, gel and emulsion dosage form mucilage. Among them, the first five are mainly for external use, and the last one is for gastroscopy, digestive tract and other endoscopy. It is clinically used for mucosal surface anesthesia, skin analgesia and antipruritic. |
| properties | white crystalline powder, slightly smelly, tattacky, slightly soluble in water, soluble in ethanol, acetone, chloroform and 60 ℃ water. Stable in the air, when heated, the decomposition solution becomes turbid and precipitates oil, and is stored in a closed and dark. |
| pharmacodynamics | the mechanism of action is mainly nerve block, local anesthesia has fast effect, strong pharmacological effect and long duration, low toxicity, analgesic, antipruritic and bactericidal effects. Fig. 1 is dyclonine hydrochloride solution |
| pharmacokinetics | injection is irritating, only used for appearance, and has strong penetration to mucosa. |
| synthesis method | piperidine hydrochloride is prepared by reacting piperidine with concentrated hydrochloric acid, p-butoxyacetophenone and polyformaldehyde are added to it, and then concentrated hydrochloric acid is added as catalyst to obtain crude dyclonine hydrochloride. the crude dyclonine hydrochloride is dissolved in anhydrous ethanol, activated carbon is added, heated and refluxed, filtered while hot, the filtrate is stirred and cooled, and filtered, vacuum drying of dyclonine hydrochloride boutique. Fig. 2 shows the synthetic route of dyclonine hydrochloride |
| use | used for burns, abrasions, prurigo, insect bites, ulcers, bedsores, hemorrhoids, etc., and also used for urethra and stomatology mucosal anesthesia. (2015-12-02) Used for topical anesthesia. |
| precautions | 1. people allergic to dyclonine hydrochloride are prohibited. 2. The elderly, patients with acute diseases, severe damage to the digestive tract mucosa and children reduce the dose as appropriate. 3. Pregnant women with caution and children must use under the supervision of adults. 4. It is forbidden when the properties of this product change. 5. This medicine is kept out of reach of children. |
| usage and dosage | topical 1% ointment, cream, also use 0.5% solution, mucosal anesthesia with 1% solution 10ml. |
| preparation and specification | make 0.5% ~ 1% solution; 1% ointment; 1% cream. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-rat LD50: 33 mg/kg; Abdominal cavity-mouse LD50: 52 mg/kg |
| stimulation data | skin-rabbit 1% mild; Eye-rabbit 2% severe |
| flammability hazard characteristics | thermal decomposition discharges toxic nitrogen oxides, hydrogen chloride smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | water, dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent |
Last Update：2024-04-09 20:49:11
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View History
dyclonine hydrochloride
113484-74-5
2417089-74-6
2,6-DIMETHYLPHENYL ISOCYANIDE
甲氧基异丙醇
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VANILLYLMANDELIC ACID
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azocane-1-carboxamide
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113484-74-5
2417089-74-6
2,6-DIMETHYLPHENYL ISOCYANIDE
甲氧基异丙醇
11130-21-5
VANILLYLMANDELIC ACID
间氯苯甲醛
azocane-1-carboxamide
10297-06-0